Dr. Steven N. Kaganove
Research Scientist

Areas of Research Interest

  • Dendritic polymers
    Polyamidoamine (PAMAM) dendrimers; Hyperbranched polymers synthesized via Ax + By bimolecular non-linear polymerization reactions (BMNLP); Self-assembly of amphiphilic dendrimers and hyperbranched polymers, and their interfacial properties; Silicon-containing dendrimers and hyperbranched polymers; Commercial applications of poly(amidoamine-organosilicon) (PAMAMOS) dendrimers; Dendrimers and hyperbranched polymers constructed from perfluorinated monomers; Use of these materials in sensor, biomedical drug delivery, surface and vapor phase decontamination applications
  • Polyhedral oligosilsesquioxanes (POSS)
    Synthesis of amphiphilic PAMAM-POSS constructs for specialized applications
  • Polydiacetylenes (PDA)
    Synthesis of colorimetric PAMAM-polydiacetylene (PDA) constructs for sensing applications
  • Polyelectrolyte multilayers (PEM) constructed by layer-by-layer (LbL) self assembly methods
    Use of PAMAMs and other novel dendritic building blocks in the construction of polyelectrolyte multilayers (PEM)

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Areas of Expertise

  • Antimicrobial/sporicidal surface coatings
  • Colorimetric chemical sensor materials
  • Polymeric blood substitutes
  • Low dielectric constant materials


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Education

B.A. Grinnell College (1985, Chemistry)
Ph.D. University of California, Los Angeles (1993, Organic Chemistry)


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Research Experience

  • Indiana University, Postdoctoral Fellow, 1993-1994
  • Pacific Northwest National Laboratory, Richland, WA, Postdoctoral Fellow, 1994-1998
  • Michigan Molecular Institute, Midland, MI, Research Associate, 1998-2000
  • Michigan Molecular Institute, Midland, MI, Associate Scientist, 2000-2003
  • Michigan Molecular Institute, Midland, MI, Senior Associate Scientist, 2003-2010
  • Michigan Molecular Institute, Midland, MI, Research Scientist, 2010-present


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Patents

  1. N-Halamine Based Biocidal Coatings Composed of Electrostatically Self-Assembled Layers, Kaganove, S.N., US Patent Application #61/281,498, filed November 18, 2009.
  2. Nano-structured blood substitutes, Kaganove, S.N.; Satoh, P.; Dvornic, P.R., (Michigan Molecular Institute), US 0147414 A1 (2006)
  3. Solid-state colorimetric biosensors comprised of dendritic polymer networks, Dvornic, P.R.; Kaganove, S.N.; Sarkar, A. (Michigan Molecular Institute), US 7141437 (2006)
  4. Nano-scaled dendrimer-based colorimetric biosensors, Kaganove, S.N.; Dvornic; P.R. (Michigan Molecular Institute), US 7045367 (2006)
  5. Strongly hydrogen-bond acidic polymer and methods of making and using, Grate, J.W.; Kaganove; S.N. (Battelle Memorial Institute), US 6015869 (2000)


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Dissertation

A New Synthesis of Adamantane-2,6-dione, Ph.D. Thesis, Department of Chemistry, University of California, Los Angeles, 1993


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Awards

  • Products Research Fellowship, University of California, Los Angeles, 1986
  • Chemistry Alumni Prize, Grinnell College, 1985


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Teaching Experience

Teaching Assistant in Chemistry, University of California, Los Angeles, 1986-1990


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Scientific and Professional Societies

American Chemical Society (Member)


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Papers

    1. A Comparative Study of Amphiphilic PAMAM Dendrimers at the Air-Water Interface with Different Hydrophobe Attachment Groups, Zhang, T.; Dvornic, P.R.; Kaganove, S.N., Langmuir, 2007, 23(21), 10589-10597.
    2. Colorimetric Biosensors Based on Polydiacetylene (PDA) and Polyamidoamine (PAMAM) Dendrimers, Sarkar, A.; Kaganove, S.N.; Dvornic, P.R.; Satoh, P.S., Polymer News, 2005, 30(12), 370-377.
    3. Hydrogen-Bond Acidic Hyperbranched Polymers for Surface Acoustic Wave (SAW) Sensors, Hartmann-Thompson, C.; Hu, J.; Kaganove, S.N.; Keinath, S.E.; Keeley, D.L.; Dvornic, P.R., Chem. Mater., 2004, 16(25), 5357-5364.
    4. Nanostructured Cosslinkable Micropatterns by Amphiphilic Dendrimer Stamping, Kohli, N.; Dvornic, P.R.; Kaganove, S.N.; Worden, R.M.; Lee, I., Macromol. Rapid Commun., 2004, 25(9), 935-941.
    5. Colorimetric Polydiacetylene Nano-Sensors Based on PAMAM Dendrimer Templates, Sarkar, A.; Satoh, P.S.; Dvornic, P.R.; Kaganove, S.N., Polymer Preprints, 2003, 44(2), 191-192.
    6. Steplike Response Behavior of a New Vapochromic Platinum Complex Observed with Simultaneous Acoustic Wave Sensor and Optical Reflectance Measurements, Grate, J.W.; Moore, L.K.; Janzen, D.E.; Veltkamp, D.J.; Kaganove, S.; Drew, S.M.; Mann, K.R., Chem. Mater., 2002, 14(3), 1058-1066.
    7. Inverse Least-Squares Modeling of Vapor Descriptors Using Polymer-Coated Surface Acoustic Wave Sensor Array Responses, Grate, J.W.; Patrash, S.J.; Kaganove, S.N.; Abraham, M.H.; Wise, B.M.; Gallagher, N.B., Anal. Chem., 2001, 73(21), 5247-5259.
    8. Carbosiloxane Polymers for Chemical Sensors, Grate, J.W.; Kaganove, S.N.; Nelson, D.A., Chemical Innovation, 2000, 30(11), 29-37.
    9. Hydrosilylation: A Versatile Reaction for Polymer Synthesis, Grate, J.W.; Kaganove, S.N., Polymer News, 1999, 24(5), 149-155.
    10. Hydrogen Bond Acidic Polymers for Surface Acoustic Wave Vapor Sensors and Arrays, Grate, J.W.; Patrash, S.J.; Kaganove, S.N.; Wise, B.M., Anal. Chem., 1999, 71(5), 1033-1040.
    11. Examination of Mass and Modulus Contributions to Thickness Shear Mode and Surface Acoustic Wave Vapor Sensor Responses Using Partition Coefficients, Grate, J.W.; Kaganove, S.N.; Bhethanabotla, V.R., Faraday Discussions, 1997, 107, 259-283.
    12. Comparisons of Polymer/Gas Partition Coefficients Calculated from Responses of Thickness Shear Mode and Surface Acoustic Wave Vapor Sensors, Grate, J.W.; Kaganove, S.N.; Bhethanabotla, V.R., Anal. Chem., 1998, 70(1), 199-203.
    13. Hybrid Organic/Inorganic Copolymers with Strongly Hydrogen-Bond Acidic Properties for Acoustic Wave and Optical Sensors, Grate, J.W.; Kaganove, S.N.; Patrash, S.J.; Craig, R.; Bliss, M., Chem. Mater., 1997, 9(5), 1201-1207.
    14. Improvements in the Synthesis of Adamantane-2,6-dione and Preparation of the Novel Adamantane-2,6-dione Mono-Ketal, Ayres, F.D.; Khan, S.I.; Chapman, O.L.; Kaganove, S.N., Tetrahedron Lett., 1994, 35, 7151-7154.
    15. Effect of α-Cyclodextrin Complexation on a General Base Catalyzed Photo-Smiles Rearrangement, Wubbels, G.G.; Sevetson, B.R.; Kaganove, S.N., Tetrahedron Lett., 1986, 27, 3103-3106.

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Lectures and Presentations

    1. Synthesis and Surface Grafting of PAMAM Dendrimers with Biocidal N-Halamine End-Groups, S.N. Kaganove, T. Zhang, K. Niec, and S. Cendrowski, Multifunctional Nanoscale Materials for the 21st Century, An International Symposium at The Center for Nanoscale Materials, Argonne National Laboratory, Argonne, IL, March 6, 2009.
    2. A Langmuir Trough Study of Amphiphilic PAMAM Dendrimers, and Investigation of their Use as Supports for Bilayer Lipid Membranes, S.N. Kaganove, Department of Chemical and Environmental Engineering, University of Toledo, Toledo, OH, March 13, 2008.
    3. A Langmuir Trough Study of Amphiphilic PAMAM Dendrimers, and Investigation of their Use as Supports for Bilayer Lipid Membranes, S.N. Kaganove, Department of Chemistry, Central Michigan University, Mount Pleasant, MI, October 22, 2007.
    4. Dendritic Polymer Approaches for the Decontamination of Vapor Phase Cyanide, S.N. Kaganove, T. Zhang and P.R Dvornic, 2006 ACS Central Regional Meeting, Frankenmuth, MI, May 19, 2006.
    5. Polyamidoamine-Organosilicon (PAMAMOS) Dendrimer Coatings for Vapor Phase Cyanide Removal, S.N. Kaganove, T. Zhang, and P.R. Dvornic, Pacifichem 2005, International Chemical Congress of Pacific Basin Societies, Honolulu, HI, December 17, 2005.
    6. Uses of Dendritic Polymers in Chemical Sensing Applications, S.N. Kaganove, A. Sarkar, C. Hartmann-Thompson, J. Hu, D.L. Keeley, P.R. Dvornic and S.E. Keinath, 61st ACS Midland Section Fall Scientific Meeting, Midland, MI, October 14, 2005.
    7. Polyamidoamine-organosilicon (PAMAMOS) Dendrites Coatings for Vapor Phase Cyanide Removal, S.N. Kaganove, T. Zhang and P.R. Dvornic, 4th International Dendrimer Symposium IDS-4, Mount Pleasant, MI, May 18-21, 2005.
    8. PAMAMOS: A New Class of Siliconized Dendrimers, P.R. Dvornic, S.E.Scheibert, S.N. Kaganove and A. Sarkar, 4th International Dendrimer Symposium IDS-4, Mount Pleasant, MI, May 18-21, 2005.
    9. Colorimetric Biosensors Based on PAMAM Dendrites - Polydiacetylene Nano-Constructs, A. Sarkar, P. Satoh, P.R. Dvornic and S.N. Kaganove, 4th International Dendrimer Symposium IDS-4, Mount Pleasant, MI, May 18-21, 2005.
    10. C. Hartmann-Thompson, J. Hu, S.N. Kaganove, S.E. Keinath, D.L. Keeley and P.R. Dvornic, “Hydrogen-Bond Acidic Hyperbranched Polymers for Surface Acoustic Wave (SAW) Sensors”, 4th International Dendrimer Symposium IDS-4, Mount Pleasant, MI, May 18-21, 2005.
    11. Colorimetric Polydiacetylene Nano-Sensors Based on PAMAM Dendrimer Templates, A. Sarkar, P.S. Satoh, P.R. Dvornic and S.N. Kaganove, 226th ACS National Meeting, New York, NY, September 7, 2003.
    12. Colorimetric Nano-Sensors Based on Photo-Polymerizable Amphiphilic PAMAM Dendrimes, A. Sarkar, P.S. Satoh, P.R. Dvornic and S.N. Kaganove, 38th National Organic Symposium, Indiana University, Bloomington, IN, June 8, 2003.
    13. Hydrosilation Polymerization: a Versatile Approach to the Synthesis of New Carbosiloxane Polymers for use as Sensor Materials, S.N. Kaganove and J.W. Grate, 215th National Meeting of the American Chemical Society, Dallas, Texas, April 2, 1998.


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Synergistic Activities

  • ACS Local Midland Section Awards Committee Member, 2003-present
  • Adjunct Professor, Central Michigan University, 2005-present
  • Adjunct Professor, Michigan State University, 2007-present

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Advisors

  • Graduate Advisor: Orville L. Chapman, University of California, Los Angeles (deceased)
  • Postdoctoral Advisor: L. K. Montgomery, Indiana University
  • Postdoctoral Advisor: Jay W. Grate, Pacific Northwest National Laboratory
  • Postdoctoral Advisor: Petar R. Dvornic, Michigan Molecular Institute

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